Document Details

Document Type : Thesis 
Document Title :
STUDY OF SOME INFLAMMATORY MEDIATORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
دراسة لبعض وسائط الالتهابات في المرضى المصابين بتدهن الكبد الغير كحولي
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Non-alcoholic fatty liver disease (NAFLD) is the worldwide most common form of liver disease becoming a major health problem in developed and developing countries due to its high prevalence and linkage with many health problems such as diabetes, obesity, insulin resistance and metabolic syndrome. It is important to find noninvasive markers for the detection of the earlier stage of the disease. Resistin and osteoprotegerin (OPG) are novel adipokines that suggested to have a contributing role in NAFLD pathogenesis. The aim of the study is to investigate the serum levels of resistin and OPG in patients with NAFLD in a trial to find if there is any association between these markers and NAFLD. To explore also if these adipokines show significant difference from the control levels, they may be used as non-invasive biomarker for the NAFLD in the future. Methods: In this case control study a total of 43 patients (simple steatosis and advanced NAFLD) were diagnosed and confirmed by the fibroscan in the King Abdul-Aziz University Hospital in Jeddah, Saudi Arabia. We obtained the clinical data and preformed serum resistin, OPG, biochemical mesuerments in the patients, (body mass index (BMI) 80.1±19.4 kg/m2), and age and sex matched19 controls. Results: Resistin was higher in advanced NAFLD and simple steatosis patients (9.66 ± 5.77 vs. 8.18 ± 3.55 ng/ml) compared to control group (7.75 ± 2.87) (P= 0.367). OPG was lower in advanced liver and simple steatosis patients (209.25 ± 47.637 vs. 208.66 ± 74.722 ng/ml) compared with controls ( 216.315 ± 43.623 ng/ml) (P = 0.888). Only ALT showed inverse significant correlation with serum resistin levels in the disease (p=0.050). Fasting glucose, AST and ALT were showed significant correlation with OPG levels in the disease (p= 0.046; p= 0.012 and p= 0.012) Conclusion: Resistin and OPG did not show a remarkable link with NAFLD as there was no significant difference between patients with advanced liver disease and those with simple steatosis compared to controls. Further studies with larger numbers of patients would be recommended to investigate enough number of patients in each stage. 
Supervisor : Dr. Fayza Fawaz Al Fayez 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2017 AD 
Added Date : Wednesday, December 13, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ابتسام خالد العطاسAlattas, Ibtesam KhaledResearcherMaster 

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