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Document Type |
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Thesis |
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Document Title |
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The Protective Effect of Fish Oil on Male Rats Exposed to Lead Histological and Physiological study التأثير الوقائي لزيت السمك على ذكور الجرذان المعرضة للرصاص دراسة نسيجية وفسيولوجية |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Lead toxicity is a common clinical problem as a result of environmental pollution. It
Initiates free radicals generations that result in organ damage due to oxidative
Stress. Fish oil is well known for its beneficial antioxidant activity.
The present study aimed to examine the effect of fish oil against biochemical and histological changes of vital organs (Liver, kidney and testis) in rat. Forty adult male rats were divided into four groups (N=10). The first group served as control and received daily normal saline (0.9 ml). The second group was exposed to Pb (150 mg/kg) three times a week via oral gavage. Rats of the third group (10) rats were treated with fish oil (0.650 mg/kg) orally. The fourth group was supplemented with fish oil (0.650 mg/kg) daily plus Pb 150 mg/kg). After six weeks, histological and physiological alterations for the 3 organs were estimated Significant alteration of serum T.Protein (3.05±0.98) , Albumin (1.50±0.39),T.G(110.90±6.9),LDL(192.74±27.82), HDL (13.58±2.0) , ALP (136.70±18.99), Glucose (173.00±20.16), Urea (37.60±6.89), UC (9.26±0.88), creatinine (1.43±0.48) were detected in Pb treated rats. While a significant preservation of normal serum blood (ALT) Alanine aminotransferase (22.40±6.50) was observed in fish oil plus Pb treated rats.
Histopathological observation of liver, kidney and testis of Pb-treated rats showed changes indicating oxidative damage in liver (hepatocytes necrosis and central vein dilation and congestion), Kidney (glomerulus atrophy and renal tubules dilation and casts), Testis (seminiferous tubules germ cell degeneration and loss). The present study revealed that fish oil attenuated the physiological and histological alterations induced by Pb. In addition, the result of this study suggested that chemical antioxidants properties of fish oil could be attributed to the protective effect against toxicity induced by Pb |
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Supervisor |
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Prof. Dr. Samar Omar Abdullah Rabah |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Added Date |
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Wednesday, May 20, 2020 |
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Researchers
| رنا عبد الله الزهراني | ALzhrani, Rana Abdullah | Researcher | Master | |
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