Document Details
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Document Type |
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Thesis |
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Document Title |
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Effect of Lepidium Sativum Seeds on Inflammatory Activity in Rats تأثير بذور حب الرشاد على النشاط الإلتهابي في الجرذان |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Garden cress (Lepidium sativum, LS) seeds are used in traditional medicine to treat diseases and enhance immunity, with no sufficient proof. This study was done to determine the effects of ground LS seeds on health and inflammation in rats. This is the first study to determine the effects of LS seeds on IgM levels and the difference in hematological parameters between two experimental periods. Thus, the differential complete blood count; concentrations of IgM, interleukin 6 (IL-6), C-reactive protein (CRP), and liver, heart, and skeletal muscle enzymes; body weights and gains; organs weights; and feed and water intakes were determined at two experimental periods. Young male Wistar albino rats were divided into a low dose (LD, 12 rats, 10% LS seeds) and a high dose (HD, 12 rats, 15% LS seeds) group ingesting ground LS seeds mixed with the regular feed (w/w) daily, and a control group (12 rats) administered with the regular feed. Blood samples were collected at 31 and 39 days of the experiment, after which the rats were sacrificed. Comparing the results to the control, LS seeds led to higher body and organs weights, and lower feed and water intakes for both experimental periods. Hemoglobin and IgM levels were lower for the shorter experimental period only. Total and differential WBC counts and percents were higher for all cells, except for the lymphocytes counts (unchanged) and percents (lower). Serum and spleen IL-6 concentrations were higher. Liver, heart, and skeletal muscle enzymes; and CRP concentrations were unchanged in serum and tissues, while the liver alanine aminotransferases concentration was lower for the HD group compared to the control. Thus, LS seeds did not lead to toxic or ill effects while they influenced humoral adaptive and innate immunities, and inflammation, with these effects showing a dependence on the period of consumption. |
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Supervisor |
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Dr. Sawsan Hassan Mahassni |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Added Date |
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Sunday, May 17, 2020 |
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Researchers
| خلود خالد نابلسي | Nabulsi, Kholood Khaled | Researcher | Master | |
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