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Document Type |
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Thesis |
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Document Title |
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EFFICACY OF LEPIDIUM SATIVUM L. SEEDS AS A PROTECTIVE AGENT AGAINST CARBON TETRACHLORIDE INDUCED PANCREATIC INJURY IN NEW ZEALAND RABBITS فاعلية بذور حب الرشاد كعامل حماية ضد الإيذاء المستحث برباعي كلوريد الكربون للبنكرياس في الأرانب النيوزلندية |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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The present study investigated the protective efficacy of Lepidium sativum seeds (LSS) against CCl4 induced pancreatic injury in New-Zealand rabbits. Rabbits were randomly distributed into 2 main groups. Group A, represented normal group (n = 15) was divided into three subgroups A1 (untreated control), A2 and A3 received 0, 200 and 400 mg/kg bw of LSS respectively in their diet daily. Group-B represented pancreatic group (n=30) was subcutaneously injected with CCl4 (0.5 ml/kg bw) starting from day one of the experiment till the end of the study and equally divided into 3 subgroups, B1 received normal standard diet, B2 & B3 received 200 & 400 mg/kg bw of LSS respectively in their diet daily. Five rabbits of each subgroup were decapitated 5 & 10 weeks post experimental running. Data obtained revealed a significant improvement in plasma levels of glucagon, insulin, somatostatin, pancreatic amylase and lipase as well as plasma glucose in groups B2 and B3 for 5 and 10 weeks as compared with CCl4 treated rabbits. Antioxidant system in pancreatic tissues were significantly recovered in treated groups compared with untreated. Approximately complete repair of DNA damage was significant after feeding rabbits with 200 mg & 400 mg/ kg.bw LSS. The histological findings of pancreas showed marked improvement in the pancreatic cellular architecture with increased in size and number of islets post LSS treatment. In conclusion, LSS administration was able to restore all the biochemical parameters towards normalization due to its active ingredients components (cis-Methyl 11-eicosenoate, 9,12,15-Octadecatrienoic acid, methyl ester, 11-Octadecenoic acid, alpha.-Linolenic acid and Sinapinic acid). |
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Supervisor |
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Dr. Mohamed Kamel Abo-Golayel |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2019 AD |
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Co-Supervisor |
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Dr. Mazin Abdulaziz Zamzami |
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Added Date |
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Wednesday, December 4, 2019 |
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Researchers
| خالد عبدالعزيز زاكي | Zaki, Khaled Abdulaziz | Researcher | Master | |
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