Document Details
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Document Type |
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Thesis |
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Document Title |
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THE PROTECTIVE AND THERAPEUTIC POTENTIALS OF ARABIC GUM ACACIA AGAINST DIABETIC INDUCED PERIPHERAL NEUROPATHY IN RATS تأثير الصمغ العربي على الأطراف العصبيه عند الفئران المصابه بالسكري |
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Subject |
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Faculty of Medicine |
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Document Language |
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Arabic |
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Abstract |
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Diabetic peripheral neuropathy (DPN) is a frequent complication of both types of diabetes mellitus (DM) with a reported high rate in the Middle East asover the world. Arabic gum (AG) is reported to have pharmacological effects as anti-diabetic, anti-nociceptive, antioxidant and anti-inflammatory effects.The aim of this study was to assess the anti-diabetic, anti-oxidative and hypolipidemic action of AG and its role in promoting the protection and the functional recovery from diabetic neuropathy developed in an experimental model of diabetic neuropathy in rats. In this study 60 adult male rats were utilized. They were randomly divided into six groups: GI: control group, GII: AG-treated group, GIII: untreated diabetic group (the rats were made diabetic by injection of streptozotocin and left without any treatment to the end of the study period, GVI: diabetic and metformin group (the rats were made diabetic, then treated by metformin for 30 days), GV: diabetic, metformin and AG (the rats were made diabetic, then started treatment after 60 days with metformin and AG for 30 days i.e. "therapeutic group", GVI: diabetic, metformin and AG group (the rats were made diabetic and treated immediately with metformin and AG to the end of the study period i.e. "protective group". At the end of experimental period, the rats of different groups were subjected to the assessment of behavioral changes and locomotor activity through an open field and hot plate test. Then, the rats were sacrificed where the blood was taken to estimate serum glucose, insulin levels, lipid profile and parameters of oxidative stress. Also, the sciatic nerve was dissected, processed and examined histopathologically using light and electron microscope. The results of this work showed that behavioral changes and the locomotor activity of the untreated diabetic rats were significantly reduced compared to the control group while they were significantly increased in metformin and AG therapeutic and protective groups. Also, the serumglucose, insulinlevels, lipid profile and antioxidants parameters were significantly improved in metformin and AG therapeutic and protective groups compared to the untreated diabetic group. Histopathologically, at the light and ultrastructural levels, the sciatic nerve changes were improved in all the treated groups especially in the protective diabetic group. It could be concluded that AG had a potential protective and therapeutic role on DPN. |
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Supervisor |
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Prof. Hamid A. Saleh |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1440 AH
2019 AD |
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Co-Supervisor |
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Dr. Gamal S. Abd El-Aziz |
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Added Date |
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Thursday, September 12, 2019 |
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Researchers
| هيله محمد المحيميد | Al-mohaimeed, Hailah Mohammed | Researcher | Doctorate | |
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