Document Details
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Document Type |
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Thesis |
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Document Title |
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SERUM CHEMERIN LEVELS IN NORMAL AND HYPOTHYROID SAUDI WOMEN مستويات شيمرين مصل الدم في النساء السعوديات الأصحاء ومرضى قصور الغدة الدرقية |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Chemerin is a protein that is secreted by adipose tissue, it is considered as novel
adipokine that plays an essential role in adipogenesis, glucose metabolism, and insulin
resistance. However, its concentration is influenced by many factors including
individual’s body mass index (BMI), age, gender and high blood pressure. It also acts
as chemokine, adipokine and growth factor; which play an important role in
inflammatory reactions and immune response in different physiological reactions.
Chemerin have complex interactions with endocrine system, its serum levels are found
to be affected by thyroid hormones status. The aim of the study is to compare serum
concentrations of chemerin and pituitary-thyroid axis hormones in normal and
hypothyroid Saudi females of different body weights, to provide new data on the
relationship between chemerin levels and thyroid function. The participants consent
was obtained. Study was conducted on 100 females with an established diagnosis of
hypothyroidism, participants were aged between 30 and 45 years, BMI was measured,
and the biochemical variables including fasting chemerin levels, thyroid function, lipid
profile, glucose, insulin, and homeostatic model assessment-insulin resistance
(HOMA-IR) werealso measured.
As far as we are aware, this study is the first to assess the relationship between
chemerin and hypothyroidism in Saudi women. Our results showed that chemerin has
high concentrations in obese hypothyroid women (OH) and in the obese control (OC)
groups with no significant differencesin hypothyroid women with normal bodyweight
group (NH) compared to normal bodyweight controls. In conclusion, the results of this
study clearly showed that chemerin levels are increased in obese women, and this
suggests that BMI might play an important role in regulating chemerin levels in
hypothyroidism independent of the thyroid hormones status.
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Supervisor |
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Dr. Huda Al Doghaither |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1440 AH
2019 AD |
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Co-Supervisor |
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Dr. Ulfat Omar |
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Added Date |
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Monday, August 26, 2019 |
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Researchers
| ود سعود داود | Dawood, Wed Saud | Researcher | Master | |
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