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Document Type |
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Thesis |
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Document Title |
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Effect of Boswellia carteri and Black Raisins (Vitis vinifera) on Potential Alzheimer's Disease Induced by Aluminium Chloride (AlCl3) in Male Albino Rats تأثير اللبان الذكر ( Boswellia carteri) والزبيب الأسود Vitis vinifera ) ) على مرض الزهايمر المحتمل المستحدث بواسطة كلوريد الألومنيوم في ذكور الجرذان البيضاء |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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Alzheimer's Disease (AD) is now the most common cause of dementia. The present experimental study investigate the effects of B. carteri and black raisins and their combination on aluminium chloride (AlCl3) induced AD in adult male albino rats. Seventy-two adult male Albino Wistar rats were used in this study and were randomly distributed into nine groups. Rats of the first group were served as controls. Animals of the second, third and fourth groups were supplemented with B. carteri aquatic extract (500 mg/kg b.wt/day), raisin (26 g/kg b.wt/day), and B. carteri and raisin (500 mg/kg b.wt/day, 26 g/kg b.wt/day respectively). Rats of the fifth group were treated with AlCl3 (model of AD) (100 mg/kg b.wt/day). Animals of the sixth, seventh, eighth and ninth groups were treated with (B. carteri + AlCl3), (raisin + AlCl3), (B. carteri + raisin+AlCl3) and (rivastigmine+ AlCl3) respectively. After eight weeks, the behavioral test (maze learning test) was done in rats to assess learning and memory, biochemical assays in cortex and hippocampus homogenate, and histopathological studies were made in hippocampus area to determine the effect of B. carteri aquatic extract and black raisin and their combination on AlCl3 induced AD in rats. Aluminium chloride exposure significantly decreased the learning and memory in the maze learning test. Also, significant increased of cortex and hippocampus homogenate levels of acetylcholinesterase and lipid peroxide but significant decreased in dopamine, norepinephrine, gamma-aminobutyric acid, reduced glutathione, oxidase glutathione and superoxide dismutase. Histopathological examination of hippocampus sections showed severe changes including increase of degenerated cells and structural damage in AlCl3 treated rats. Treatment of rats with B. carteri aquatic extract and raisin and their combination showed a pronounced attenuation on the damage caused by AlCl3 associated with improvement of behavioral, biochemical and histopathological alterations. This study shows that chronic oral administration of B. carteri and raisin and their combination have neuroprotective effect and improve the learning and memory in AD rats models and these effects may be through their antioxidant properties. |
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Supervisor |
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Dr. Ebtisam Abdullah Bawazir |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1440 AH
2019 AD |
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Added Date |
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Thursday, May 9, 2019 |
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Researchers
| رباب محمد الجراري | Aljarari, Rabab Mohammed | Researcher | Doctorate | |
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