Document Details
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Document Type |
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Thesis |
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Document Title |
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ASSOCIATION OF HYPERTHYROIDISM WITH SERUM CHEMERIN LEVELS IN SAUDI WOMEN علاقة فرط نشاط الغدة الدرقية مع مستويات شيميرين مصل الدم في النساء السعوديات |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Chemerin is adipokines that secreted from adipose tissue and play important role in regulate lipid and carbohydrate metabolism. The aim of our study was to assess the possible potential role of serum chemerin levels and hyperthyroidism in Saudi Women. A total of 140 women participated in this study. The women were divided into 70 women with hyperthyroidism known as the experimental group, and 70 euthyroid healthy participants known as the control group. Anthropometric parameters including Body Mass Index (BMI) and Waist- to- Hip Ratio (WHR) were measured. Biochemical parameters including chemerin levels, thyroid function tests, glucose, insulin, lipid profile, and insulin resistance were also determined. The results showed that Serum chemerin level, glucose, insulin resistance, and BMI significantly increased (P < 0.001 - P < 0.01) in hyperthyroidism when compared with the control group. On the other hand, lipid profile including LDL-C and cholesterol were significantly lower (P < 0.05 - P < 0.01). Moreover, no significant differences (P > 0.05) in HDL-C and triglyceride were observed between the two groups. Our study also showed that chemerin level were positively correlated with age, BMI, triglyceride, WHR, fasting glucose, insulin, and HOME-IR, but were negatively correlated with HDL-C. There are no evident relationships with thyroid hormones. The results of the study indicate novel associations between chemerin levels and hyperthyroidism in Saudi women. The findings of the study showed high levels of chemerin concentrations and high BMI in these patients, and this suggests that BMI might play role in regulating chemerin levels in hyperthyroid patients, independent of thyroid hormone. |
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Supervisor |
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Dr. Ulfat Omar |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Co-Supervisor |
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Dr. Sawsan Rahimulddin |
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Added Date |
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Monday, September 3, 2018 |
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Researchers
| إيمان مطلق الشيخ | Al Shaikh, Eman Motlaq | Researcher | Master | |
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