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Document Type |
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Thesis |
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Document Title |
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SYNTHESIS AND BIOLOGICAL EVALUATION OF HETEROCYCLIC NITROGEN AND OXYGEN DERIVATIVES AS ANTICANCER AND ANTIVIRAL AGENTS تشييد بعض مشتقات الحلقات الغير متجانسة المحتوية علي النيتروجين والاكسجين و تقييم فعاليتها البيولوجية كمضادات للسرطان ومضادات للفيروسات |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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As described by American Cancer Society, despite the progress made in the feild; cancer is still considered a serious threat for human life. It is the second most common cause of mortality worldwide. Therefore, such rapid spread of cancer has stimulated an unprecedented level of medicinal chemistry research activity directed towards the search for new structure leads that may be of use in designing novel antitumor drugs. On the other hand, hepatitis-C virus (HCV) is believed to be a risk factor for Hepatocellular carcinoma as its carcinogenetic effect has been discovered over the last decade. In this view, much interest has been focussed on nitrogen and oxygen Heterocyclic systems since they are proved to be biological versatile compounds possessing variety of activities. Among these, wide range of chemotherapeutic activities have been ascribed to pyrans and pyridines derivatives including the anti-microbial, anti-tubercular, anti-amoebic, anti-parasitic, anti-viral and a variety of anti-cancer activities. Motivated by these facts, and in continuation in our search for new potentially active chemotherapeutic molecules, and our on-going interest in the chemistry of Bio-Active Heterocyclic Compounds , a series of pyrans, pyridines and pyrimidines derivatives comprising some biologically active rings were synthesized. This combination is suggested in an attempt to investigate the influence of such hybridization on the anticipated anticancer and/or antiviral activity. The assigned structures were based on microanalysis and spectral data (IR, 1H-NMR, 13C-NMR). Moreover, some of the target compounds were subjected to the Bioassay-Cell Culture laboratory, National Research Centre (NRC) to screen their anticancer activity. In the same time, some compounds were selected and investigated for their in vitro effect on the replication of hepatitis-C virus (HCV) . |
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Supervisor |
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Prof. Dr. Hassan M. Faidallah hi |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Co-Supervisor |
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Prof. Dr. Tariq R. Soba |
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Added Date |
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Tuesday, July 10, 2018 |
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Researchers
| خالد مولاي العافية | Al Aafia, Khaled Moulay | Researcher | Doctorate | |
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