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Document Type |
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Thesis |
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Document Title |
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SYNTHESIS OF SOME NOVEL 1,8-NAPHTHYRIDINE DERIVATIVE OF ANTICIPATED BIOLOGICAL ACTIVITY تشييد بعض مشتقات الـ 8،1- نافثيردين الجديده المتوقع لها فاعلية بيولوجية |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Anew series of 2-phenyl-1,8-naphthyridin-¬ol derivatives 103a-e, 104, 105a-d, 106a-d, 107 and 108a-c , 109a-d were synthesized with chemical modification at C-3 and C-7 positions. An improvement in rates and yields were observed when the reactions carried out under ultrasonic irradiation compared with the classical method of synthesis. The newly synthesized compounds were evaluated for HepG2 cell growth inhibition. The results obtained revealed that the tested compounds possess inhibitory effect on the growth of HepG2 liver cancer cells .The mannich bases (103 a,c,d,e) show good activity ranging from (IC50: 0.03- 0.08μM) and the sturyl derivative (109 b-d) showed moderate activity (IC50: 0.18 - 0.25 μM), when comparable to that of the reference drug doxorubicin (IC50 = 0.016 μM). On other hand, compounds 105c the most potent agent and 106c which fit with molecular modeling exhibited better activity than doxorubicin with an lC50 values (0.015,0.017 μM, respectively). |
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Supervisor |
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Dr. Nisreen Said Ismail |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Added Date |
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Thursday, July 5, 2018 |
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Researchers
| ايمان سالم السلمي | Al-Salmi, Iman Salem | Researcher | Master | |
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