Document Details
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Document Type |
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Thesis |
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Document Title |
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Association between cardiometabolic risk indicators and FGF 19 in healthy individuals of different BMI grades الترابط بين مؤشرات مخاطر الايض ( الاستقلاب ) القلبي وعامل نمو الخلايا الليفيه (FGF19 ) في الافراد الاصحاء ذو مؤشرات كتله جسم مختلفه |
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Subject |
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Faculty of medicine |
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Document Language |
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Arabic |
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Abstract |
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Introduction: Obesity is currently a general public health problem worldwide and many health threatening risks are associated with it. Fibroblast growth factor 19 (FGF19) is an ileum-derived enterokine which was described initially for its role in the negative feedback loop regulating bile salt synthesis by the liver. Recently, FGF19 has emerged as an important regulator of the postprandial adaptive metabolic response. Indeed, after a meal, FGF19 stimulates glycogen and protein synthesis in the liver as well as down regulates glucose production. The contributions of FGF19 to obesity and metabolic dysfunctions remain to be elucidated and there is limited research investigating the association between FGF19 and metabolic dysregulation associated with obesity and overweight. Therefore, we aim to estimate circulating FGF 19 in healthy individuals of different BMI grades, and study its association with circulating levels of adipokines, measures of insulin resistance, liver function and lipid profile.
Subjects and Methods: 120 healthy volunteers (60 males and 60 females) were recruited from King Abdulaziz University students. Anthropometric and blood pressure measurements were taken. Venous blood was drawn in the fasted state (12-14 h). Serum concentrations of FGF19, adiponectin, leptin, and resisitn were measured manually using ELISA kit, highly sensitive CRP, blood glucose, insulin, lipid profile, and liver function tests were estimated using routine methods on Architect 8000c, homeostatic model assessment- insulin resistance (HOMA-IR), single point insulin sensitivity estimator (SPISE), and plasma atherogenic index (PAI) were mathematically calculated.
Results: Significant differences in means of hS-CRP, insulin, HOMA-IR, SPISE, ALT, GGT, HDL-C, LDL-C: HDL-C, triglycerides, PAI, leptin, adiponectin, and FGF19 were noted between different BMI groups. A significant negative correlation was found between FGF19 and BMI, measures indicating central obesity including waist circumferences (WC) and neck circumferences (NC), LDL-C: HDL-C, PAI, ALT, and GGT, while a positive correlation with insulin sensitivity, detected by SPISE was noted.
Conclusions: Serum FGF19 level appears to be inversely related to general, and abdominal obesity, as well as cardio metabolic risk indicators including oxidative stress indicated by GGT, and the liver enzyme ALT. Further studies are required to understand the possible role of FGF19 as a protective factor against cardio metabolic risk. |
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Supervisor |
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Prof. Suhad Bahijri |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Co-Supervisor |
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Dr. Ghada M.Ajabnoor |
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Added Date |
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Sunday, July 1, 2018 |
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Researchers
| يمنى حسين حجار | Hajjar, Yomna Hussein | Researcher | Master | |
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