Document Details

Document Type : Thesis 
Document Title :
STUDYING THE EFFECT OF METABOLIC SYNDROME ON THE DEVELOPMENT OF ALZHEIMER S DISEASE IN EXPERIMENTAL RATS: BIOCHEMICAL AND ULTRASTRUCTURAL STUDY.
دراسة تأثير متلازمة التمثيل الغذائي في حدوث مرض الزهايمر في فئران التجارب: دراسة كيميائية حيوية وتركيبية
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Background and aim of the work: Metabolic Syndrome (MS) is one of the fastest growing up health problems worldwide. It is a cluster of dangerous risk factors that affect person life, with the risk of developing cardiovascular disease and diabetes. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that causes dementia in approximately 10% of individuals older than 65 years. One of its typical brain lesions is neurofibrillary tangles (NFTs) that consist of hyperphosphorylated forms of the microtubule-associated protein tau that is assembled into paired helical filaments or PHFs. The aim of this study was designed to investigate the possible link between metabolic syndrome and Alzheimer’s disease as well as the possible pathophysiologic role of Amyloid Precursor Protein(APP). Materials and Methods: A total number of 45 male albino rats were enrolled; 30 Albino rats were fed on a high-fat diet [ Metabolic syndrome group (MS) ] and 15 Albino rats with normal diet[ control group]. Serum glucose, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and total anti-oxidants capacity were estimated calorimetrically. While Serum Insulin, APP were estimated by using ELISA, liver, and brain histological examination was also carried out. Results: There is a statistically significant increase in the markers of insulin resistance and oxidative stress as well as APP in metabolic syndrome rats than controls. Histologically, eleven rats of the thirty metabolic syndrome rats showed a picture of neurodegenerative changes indicating an occurrence of Alzheimer’s disease (AD). AD rats showed higher APP level than without AD rats. Moreover, AD rats showed also higher oxidative stress marker than others. In addition, the APP showed significant positive correlation with oxidative stress as well as insulin resistance markers. Conclusion: It could be concluded that metabolic syndrome could predispose to neurodegenerative diseases in the form of Alzheimer’s disease. Moreover, APP could play a role in the pathogenesis of metabolic syndrome-related neurodegenerative disorders which need further investigations. 
Supervisor : Prof. AYMAN ZAKY ELSMANOUDY 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Co-Supervisor : Dr. HANAN ALI AMIN 
Added Date : Sunday, June 3, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
يوسف صالح جمل الليلJAMAL ALLAIL, YOUSEF SALEHResearcherMaster 

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