Document Details
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Document Type |
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Thesis |
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Document Title |
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EVALUATION OF THE POSSIBLE ANTIOXIDANT EFFECTS OF PEGENUM HARMALA AND GINKGO BILOBA IN AMELIORATING ALZHEIMER’S DISEASE IN RAT MODEL تقييم التأثيرات المحتملة لمضادات الأكسدة لكل من الحرمل والجنكه بيلوبا في تحسين مرض الزهايمر في نموذج الجرذان |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder leading to dementia in the elderly population that leads to disturbances of cognitive function, difficulties in memory, disturbances in language, and impairments in activities of daily living. Increasing evidence advises that oxidative stress that is normally associated with aging is an obvious and early feature of AD and plays a role in its pathogenesis. The present study was designed to evaluate the possible neuroprotective activity of Pegenum harmala (Ph) and/or Ginkgo biloba (Gb) extract against AD in a rat model. Fifty male albino rats were divided into five groups; control group, AD treated group, and AD treated rats received either Ph (187.5 mg/kg b.wt. /day), or Gb (120 mg/kg b.wt. /day) and their combination orally for 4 weeks. Alzheimer’s was induced by chronic administrated intraperitoneal injection of scopolamine (0.7 mg kg-1, i.p.) to rats for a period of 7 days. The results revealed that the levels of Thiobarbituric acid reactive substances and Xanthine oxidase were significantly increased, even though the activities of superoxide dismutase and catalase, as well as the reduced glutathione, were significantly decreased in the brain homogenate of Alzheimer group. Additionally, brain acetylcholinesterase as well as alkaline Phosphatase, acid Phosphatase, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities were significantly increased. On the other hand, the administration of Gb, Ph and co-administration of those test herb extract acquired potential therapeutic effects on improving the neurodegenerative disorder in rats through suppressing lipid peroxidation, augmenting endogenous antioxidant enzymes, and reducing acetylcholinesterase activity in the brain. It might be concluded that a mixture extract, by its antioxidant constituents, could modulate scopolamine-induced oxidative stress and enzyme activities in the brain. |
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Supervisor |
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Dr. Nadia Mahmoud |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Added Date |
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Wednesday, May 30, 2018 |
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Researchers
| خولة حسان العنبري | AlAnbari, Khawla Hassan | Researcher | Master | |
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