Document Details

Document Type : Thesis 
Document Title :
PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF RED SEA SPONGE: CALLYSPONGIA SPESCIES
دراسة فيتو كيميائية وحيوية لإسفنج البحر الأحمر من جنس كاليسبونجيا
 
Subject : faculty of Pharmacy 
Document Language : Arabic 
Abstract : The current study had two objectives; (1) Evaluation of the hepatoprotection effects of the ethanolic extract of the different organs of Rumex cyprius in tetrachloride-induced acute liver toxicity. (2) Detection of the flavonoidal content of the Rumex cyprius by using Liquid Chromatography-Electrospray Ionization-Mass Spectrometry (LC-ESIMS). The hepatoprotection were evaluated through assessing the hepatotoxicity markers ;alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TB), total cholesterol (TC) and triglycerides (TG), oxidative stress markers, glutathione (GSH), lipid peroxidation marker malondialdhyde (MDA) and finally, activity of the antioxidant enzyme superoxide dismutase (SOD). The mechanism underlying the observed hepatoprotection activity of the extracts could be attributed to the presence of flavanoids which work as antioxidants. The detection of the flavonoidal content of the Rumex cyprius has been done by employing the LC-ESI-MS using different conditions aiming at obtaining chromatograms with good resolution. The promising peaks were extensively investigated and the identification of the compounds were achieved by comparing the obtained mass spectra with published fragmentation patterns. It is wealthy to summarize that sixteen peaks in the LC chromatogram were investigated. Conclusively, the identified compounds are flavonoids and categorized under three flavonoidal classes eight (C-glycosides), two (O- glycoside) and three (aglycone). 
Supervisor : Prof. Dr. Nadia M.Sokkar 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Co-Supervisor : Prof. Dr. Ahmed A. M. Abdel Lateff 
Added Date : Wednesday, February 14, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
إيمان سعود الجابريal-Jabri, Iman SaudResearcherMaster 

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