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Document Type |
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Thesis |
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Document Title |
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“SYNTHESIS AND CHARACTERIZATION OF β -KETO SULFONES MODIFIED CHITOSAN FOR VARIOUS APPLICATIONS” " تشييد ودراسة خصائص البيتا كيتو سلفونات المحور بالكيتوزان لعدة تطبيقات " |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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In this study, a series of chitosan based β-ketosulfone derivatives (CsB-β-KS) has been synthesized, characterized and evaluated as promising agents for two different valuable applications. These include: surface selective adsorbents for the extraction of toxic Hg (II) metal using inductively coupled plasma optical emission spectrometry (ICP-OES) and anti-cancer agents against three types of cancer cell lines: colon carcinoma cell line (HCT), liver hepatocellular carcinoma cell line (HEPG2) and breast carcinoma cell line (MCF-7). Before attempting the desired products formation, -ketosulfone derivatives with a general name: 1-(4-halophenyl)-2-(phenylsulfonyl)ethanone was firstly synthesized by the reaction of phenacyl halide with sodium benzene sulfinate. (CsB-β-KS)a-e derivatives were synthesized by chemical modification of chitosan with freshly prepared p-halo--ketosulfone derivatives in mild acidic aqueous solution. 5, 10, 15 and 20% of each p-halo--ketosulfone derivative (wt by wt) was considered with respect to chitosan weight. The chemical structures were confirmed by variable elemental and spectral analyses including: FT-IR, 1H-NMR, 13C-NMR and mass spectra. (CsB-β-KS)a-e derivatives were also characterized by various techniques such as FT-IR, 1H-NMR, XRD, FE-SEM, and thermal analyses. The synthesized compounds showed a significant biological screening against number of Gram-positive, Gram-negative bacteria and fungi. Among all tested products, (CsB-β-KS)a3 displayed higher efficiencies toward all three types of cancer under investigation with considerable low concentrations. Moreover, (CsB-β-KS)a1 derivative showed the highest adsorption efficiency. The most effective quantitatively adsorbed amount on (CsB-β-KS)a1 surface was detected at pH= 2. Besides that, the adsorption isotherm showed that the adsorption capacity of (CsB-β-KS)a1 for Hg(II) was 122.47 mgg−1 and its adsorption isotherm was in agreement with Langmuir adsorption isotherm. |
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Supervisor |
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Dr. Mahmoud Ali Hussein |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Co-Supervisor |
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Dr. Khalid Ahmad Al-amry |
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Added Date |
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Tuesday, February 13, 2018 |
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Researchers
| يوسف عوضه الغامدي | Al-Ghamdi, Youssef Odah | Researcher | Doctorate | |
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