Document Details

Document Type : Thesis 
Document Title :
STUDY OF SOME ADIPOCYTOKINES IN NON – ALCOHOLIC FATTY LIVER DISEASE
دراسة لبعض الأديبوسايتوكينات في مرض تدهن الكبد الغير كحولي
 
Subject : Faculty of Medicine 
Document Language : Arabic 
Abstract : Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world. Adipose inflammatory derived signals have been suggested to contribute to the development of NAFLD,but their exact role remained unclear. In this study, we investigated the relationship between serum adiponectin and interleukin 1 receptor antagonist (IL-1RA) levels in NAFLD patients. We conducted this case control study to assess the relationship between these parameters (adiponectin and IL-1RA) and NAFLD. We measured serum adiponectin, IL-1RA and biochemical parameters in 43 patients, (body mass index (BMI) 31.85±6.76 kg/m2 and 47.63±8.12 years) and 19 controls. Acoording to Fibroscan score, patients were devided into 2 groups: simple steatosis (n=28) and advanced NAFLD (n=15) groups. Adiponectin was lower in advanced NAFLD and simple steatosis (23.9±13.2 vs. 20.6±8.2 µg/ml) compared to controls (19.5± 9.8 µg/ml; p=.411) and IL-1RA was higher in advanced NAFLD and simple steatosis patients (438±245.89 vs. 432.68±275.76 ng/ml) compared to controls (410.26±173.83 ng/ml; p=.93). Fasting insulin showed inverse significant correlation with serum adiponectin levels in NAFLD patients (p=.03). Adiponectin and IL-1RA didn't show a link with NAFLD severity as there was no significant difference between advanced liver disease and simple steatosis subjects, and control. Large scale sample size should be taken into consideration to study enough numbers of patients in each disease stage. 
Supervisor : Dr. Fayza Al Fayez 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2017 AD 
Co-Supervisor : Dr. Hoda Gad 
Added Date : Wednesday, December 13, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ابتهال أحمد باتياهBatayyah, Ebthal AhmadResearcherMaster 

Files

File NameTypeDescription
 42952.pdf pdf 

Back To Researches Page