Document Details
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Document Type |
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Thesis |
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Document Title |
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THE CARDIO RENAL DYSFUNCTION AND BRAIN OXIDATIVE STRESS IN STREPTOZOCINE-ADMINISTRATED RATS: THE PROTECTIVE ROLE OF LYCOPENE AND LINOLENIC ACID الإعتلال القلب كلوي والضغط التأكسدي في مخ الجرذان المحقونة بالاستربتوزوسين: الدور الوقائي لليكوبين وحامض اللينولينك |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Diabetes mellitus is characterized by chronic hyperglycemia which is highly correlates to the initiation and progression of diabetic complications including generation of oxidative stress, neuropathy, nephropathy and cardiovascular diseases. Lycopene, the pigment principally responsible for the characteristic deep-red color of ripe tomato fruits and tomato products. The polyunsaturated fatty acids (PUFAs) have a major role in the prevention of coronary heart disease such as -3 fatty acid that have been suggested from epidemiologic and clinical secondary avoidance trials evidences. The aim of this study is to investigate the possible protective effect of lycopene alone or with linolenic acid against the development and progression of oxidative stress in diabetic rats induced by Streptozocin (STZ). Five groups of rats were included: Normal, Diabetic untreated, diabetic treated with either lycopene or linolenic acid or combination of both. The following parameters were evaluated. Serum glucose, glycated hemoglobin (HbA1C), advanced glycated end products (AGEs), urea, sodium, cholesterol, low density lipoprotein (LDL), alkaline phosphatase (ALP), asparatate amino transferase (GOT). Tissues (brain, heart and kidney), malonadialdehyde (MDA), nitric oxide (NO), glutathione reductase (Grase), reduced form of glutathione. The results obtained showed that the levels of serum glucose, glycated hemoglobin (Hb1Ac), advanced glycated end product (AGEs),urea, sodium, cholesterol, low density lipoprotein (LDL) alkaline phosphatase (ALP), and amino transferases (GOT,GPT) showed highly significant increased in diabetic rats compared to control . While, their level were reduced when treated with lycopene alone or linolenic acid or combined with. In tissues, the level of malonadialdehyde (MDA), nitric oxide (NO) and glutathione peroxidase (GPx) showed highly significant increased in diabetic comparing with control. While, their level extremely significant decreased when treated with lycopene alone or combined with linolenic acid. In conclusion, Lycopene or linolenic acid synergize together as free radical scavenging system that protect the damage of pancreas induce by STZ or increase insulin sensitivity. The effect of lycopene or linolenic acid varied from tissues to another tissue that depend on bioavailabilities of each to target tissues. |
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Supervisor |
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Dr. Abdulrahman Labeed Salim Al Malki |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1439 AH
2017 AD |
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Added Date |
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Monday, October 23, 2017 |
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Researchers
| يوسف احمد الخادم | Al Khadem, Yousef Ahmed | Researcher | Doctorate | |
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