Document Details

Document Type : Thesis 
Document Title :
Studies on the Antiproliferative and Antigenotoxic Activities of Costus Speciosus in Cultured Human Colon Cancer Cells
دراسة على الأنشطة المضادة للنمو والمضادة للأكسدة لنبات القسط الهندي على خلايا سرطان القولون البشرية المزروعة
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : Colon cancer is the third most common cancer and the fourth cause of death due to cancer in the collection throughout the world. Natural products have been used for the prevention and treatment of human diseases in traditional medicine. The molecular mechanisms of natural products extracts still unknown . Costus speciosus (C. speciosus) of important contained in the Sunnah popular medicinal plants. C. speciosus was characteris as an antioxidant and anti-cancer agent. The aim of the study was to analyze the anticaricogenic and genotoxic effect of C. speciosus extract compared with Diosgenin. The whole rhizome extract was compared to it is most effective and known compound Diosgnen. For this purpose, antiproliferation and antigrowth were determined using cell activity tests such as WST-1 assay and trypan blue dye exclusion staining method, in addition to Comet assay against HCT116 cell line. Furthermore, Ames test was used for the detection of genetic toxicity of the whole plant material. The results showed that with concentration of 300 μg/ml of whole plant extract almost showed 100 % of cell suppression in Human colon cancer cell line-116. The Ames test results indicated that, C. speciosus has no mutagenic effect by different concentration 10, 25, 50 and 100 μg/plate. 
Supervisor : Prof. Sufian M. ElAssouli 
Thesis Type : Master Thesis 
Publishing Year : 1438 AH
2017 AD 
Co-Supervisor : Dr. Abdulkader M. Shaikh Omar 
Added Date : Thursday, August 24, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
إيمان هلال الثبيتيAlthubaiti, Eman HillalResearcherMaster 

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