Document Details

Document Type : Thesis 
Document Title :
Association between vitamin D receptor gene polymorphisms and Hypothyroidism in Saudi population.
العلاقة بين تعدد اشكال جينات مستقبلات فيتامين د وقصور الغدة الدرقية في المجتمع السعودي
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone. It is usually a primary process in which the thyroid gland is unable to produce sufficient amounts of thyroid hormone. Vitamin D deficiency is a global health problem, its role as an immune modulator has been recently emphasized and low levels of vitamin D were observed in several autoimmune diseases. The evidence is increasingly pointing towards a significant role in reducing the incidence of autoimmune diseases. However, at this time the research on its role of vitamin D in autoimmune and thyroid disease is not conclusive. The biological effect of vitamin D is thought to occur by binding to the vitamin D receptor (VDR) which belongs to the steroid receptor super family. Although many polymorphisms exist in the VDR gene, their effect on VDR protein function and signalling is unknown. Hence this study was carried out to investigate the relationship between VDR gene polymorphisms at three restriction sites ApaI, BsmI and TaqI and the risk of hypothyroidism in Saudi population. One hundred Saudi volunteers were classified according to Thyroid–stimulating hormone (TSH) test as two groups hypothyroid patients and healthy control. The target part of VDR gene was isolated and amplified by the polymerase chain reaction (PCR). PCR products were digested by restriction enzymes: ApaI, TaqI, and BsmI and electrophoresed on agarose gel. The result shows that distribution of alleles frequency of the BsmI, TaqI and ApaI VDR gene polymorphisms differed significantly between hypothyroid patients and healthy control groups (p=.0127<0.05) for BsmI (p=.0150<0.05) for TaqI and (p=.0376<0.05) for ApaI. In conclusion, our research indicated that the VDR BsmI, TaqI and ApaI polymorphisms risk alleles are associated with hypothyroidism in Saudi population. 
Supervisor : Dr. Archana P. Iyer 
Thesis Type : Master Thesis 
Publishing Year : 1438 AH
2017 AD 
Added Date : Thursday, July 27, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
إيمان جمعان الزهرانيAl-Zahrani, Eman JamanResearcherMaster 

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