Document Details

Document Type : Thesis 
Document Title :
Interleukin- (1β) Gene Polymorphism in a Local Cases With Recurrent Aphthous Stomatitis (RAS)
دور تعدد الشكل الجيني لانترلوكين 1 بيتا في عينة محلية وعلاقته بالإصابة بمرض التهاب الفم (RAS)
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : Human interleukin -1β gene is located on chromosome 2q14 and translated into a 17 kDa protein, which is produced by various cells. It is a pro-inflammatory cytokine that plays a pivotal role in several chronic diseases. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation and differentiation. Recurrent aphthous stomatitis (RAS) is a common painful mucosal condition affecting the oral cavity and has been intensely seen among patients by clinician. It is characterized by episodic recurrent bouts of oral ulcers in an otherwise healthy individual. The pathogenesis of RAS still not fully understood. Some proposed immunological, psychological, genetic and microbiological bases. In this research, we investigated the association of polymorphism in the locus +3954 (C/T) in interleukin-1β gene with the recurrent aphthous stomatitis (RAS) among a sample of Saudi population, using modern molecular techniques for the isolation and identification of this mutation. The results indicated that the frequency of IL-1β genotype of +3954C/T (rs1143634) in the patients group was significantly different from the healthy control. No other significant differences were found in genotype and alleles frequencies between the two groups. We can conclude that, a significant correlation between the rate of interleukin-1β gene mutation and the recurrent aphthous stomatitis in the sample under study. 
Supervisor : Prof. Dr. Hassan Abdel Meguid Ibrahim Ramadan 
Thesis Type : Master Thesis 
Publishing Year : 1438 AH
2016 AD 
Added Date : Thursday, December 22, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
مديحة محمد شودريShoudari, Madiha MohammadResearcherMaster 

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