Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
Effect of Camel Urine and its Active Ingredients on Hepatitis Induced by Carbon tetrachloride in Rats تأثير بول الإبل والأجزاء الفعالة المفصوله منه على التهاب الكبد المستحدث بواسطة رابع كلوريد الكربون في الجرذان |
|
Subject |
: |
Faculty of Sciences > biological sciences department |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
Nowadays liver diseases constitute a major medical problem of worldwide proportions, so it is important to search for compounds that are more effective in their therapeutic action for Hepatic diseases. The objective of this study is to evaluate the protective effects of Camel urine and its active ingredients (PMF) on hepatitis induced in Wistar male rats by carbon tetrachloride. Eleven groups of rats were used. Rats of the first group were served as controls. Others were experimental groups, the second and third groups were exposed to paraffin oil (1ml/kg), CCL4 (1ml/kg) respectively. Rats of the fourth, fifth, sixth and seventh groups supplemented with oral PM701 (3ml/ kg), oral PMF (1.8 g /kg), IP PMF (1.1 g /kg) and IV PMF (1.1 g /kg) respectively. Animals of the eighth, ninth, tenth and eleventh groups were subjected to CCL4 plus oral PM701(3ml/ kg), CCL4 plus oral PMF (1.8 g /kg), CCL4 plus IP PMF (1.1 g /kg) and CCL4 plus IV PMF (1.1 g /kg) respectively. Physiological and histological alterations were evaluated after 7th, 21st, 42nd, 60th and 90th days. Results revealed that CCL4 induced liver fibrosis and necrosis in rats given only the control diet, which recorded the lowest body weight alterations and statistically changes of liver/body weight ratios. Moreover, rats injected with CCL4 showed significant alteration of blood aspartate transaminase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Gamma glutamyl transferase (GGT), total bilirubin (TBL), total protein (TPRT) and total albumin (TALB). Histopathologically, the liver sections from rats injected with CCL4 showed sever alterations. Interestingly, the findings of this experimental study indicated that the camel urine and its active ingredients works as hepatoprotective agents against CCL4 induced hepatic damage by reducing the physiological and histological alterations. These results suggested that the protective effect of camel urine and its active ingredients may be attributed to their antioxidant activities. |
|
Supervisor |
: |
Prof. Faten Khorshid |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1437 AH
2016 AD |
|
Co-Supervisor |
: |
Prof. Soad Shaker |
|
Added Date |
: |
Sunday, April 17, 2016 |
|
Researchers
| رنده محسن الشهري | Al-Shehri, Randah Mohsen | Researcher | Master | |
|
Back To Researches Page
|