Document Details

Document Type : Thesis 
Document Title :
The biochemical effects of some plant extracts on vascular endothelial dysfunction in type II diabetic rats
التأثيرات الكيميائية الحيوية لبعض المستخلصات النباتية على الخلل الوظيفي للخلايا الوعائية في الفئران المصابة بالسكري من النوع الثاني
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : Type II diabetes mellitus (T2DM) affects approximately 20-25% of Saudi citizens. It occurs as a result of insulin resistance (IR) especially in obese subjects. T2DM is usually accompanied with vascular endothelial cells dysfunction that considered one of the main causes of cardiovascular diseases. It was found some biochemical compounds that affect vascular endothelial cells such as (nitric oxide) NO, uric acid and vascular endothelaial growth factor (VEGF). Therefore, researchers making efforts to find synthetic or from natural origin like plants to ameliorate endothelial dysfunction. Many plants have remained as alternatives to conventional therapy in T2DM e.g. Punica granatum (pomegranate), and Lupinus albus (lupin), however, their effects on endothelial functions have not yet been studied. In this work we aimed to study the effect of these plants on some markers of endothelial dysfunction such as NO, NOS and VEGF as well as on glucose, insulin, insulin resistance, lipid profile and heart enzymes in a unique model of T2DM in rats. Our results show that the oral administration of either methanolic extract of pomegranate (PME) or total lupin extract (TLPE) in T2DM rats has significantly lowered glycemia, insulin and insulin resistance in comparison to Metformin, a well-known glucose lowering drug. In addition, PME significantly reduced uric acid and conserved NO and VEGF levels in normal levels. On the other hand, unfavorable effects regarding serum CK levels, ALT and uric acid were found post treatment with TLPE. In conclusion, the present study point out a new role for pomegranate products in ameliorating endothelial dysfunction by keeping the levels of blood NO, uric acid and VEGF in normal levels. Finally, we recommend future research to separate bioactive materials from pomegranate to produce drugs for treatment of T2DM and associated cardiovascular diseases. 
Supervisor : Dr. Mohamed F. Elshal. 
Thesis Type : Master Thesis 
Publishing Year : 1432 AH
2011 AD 
Co-Supervisor : Prof. Khalid O. Abulnaja 
Added Date : Saturday, February 19, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
خالد إبراهيم الغامدىAl-Ghamdi, Khalid IbrahimResearcherMaster 

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