Document Details

Document Type : Thesis 
Document Title :
The Effects of Maternal Low Protein Diet during Pregnancy on the Liver of Fetal Rat
تأثيرات حمية البروتين المنخفض أثناء الحمل على الكبد في أجنة الجرذان
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : The period from conception to birth is a time of rapid growth, cellular replication, differentiation and functional maturation of organ systems. Dietary deficiency of the mother has been associated with increased morbidity and mortality in the offspring and influence adult susceptibility to diet – related chronic disease. In the developing world protein deficiency will always be a concern but greater understanding of its consequences may improve long term health outcomes. As the liver has the greatest number of functions. It appeared to be of interest to study in detail the changes which take place in the liver when the protein contact is changing. Mated female rats were divided into two groups. Group I fed on standard diets containing 20% protein and group II fed on low protein diet containing 5% protein throughout pregnancy. On the 21st day of pregnancy, fetuses of both groups were extracted from the uterus. Morphometric, histological and biochemical studies were done. The morphometric results showed a significant decrease in the weight of pregnant females of group of low protein diet before their dissection and a significant decrease appeared in the number, weights and anonasal lengths of fetuses of the same group. Also a significant decrease in weight of livers of fetuses of group of low protein diet was found. Whereas a significant increase in mean area of the hepatocytes and their cytoplasm was observed. Histological results in livers of fetuses of group of low protein diet showed hepatic vacuolization and fatty infiltration in the cytoplasm using H & E stain. Increased positivity of the Oil Red O stained fat droplets and of the PAS-positive stained glycogen granules were observed. At the ultrastructural level there was irregularity of both cell and nuclear membranes and the nucleus showed circumscribed peripheral masses of heterochromatin. Mitochondria varied in shape. Fat droplets and apparent increase in glycogen granules were found in the cytoplasm. The biochemical results showed a significant decrease in the hepatic protein concentration and a significant increase in the glycogen concentration in livers of fetuses of group of low protein diet. The results in this study provides information which can be considered vital regarding the effects of low protein diet during pregnancy on the liver of the fetus. 
Supervisor : Professor Saleh Al-Karim 
Thesis Type : Master Thesis 
Publishing Year : 1431 AH
2010 AD 
Co-Supervisor : Prof. Wafaa Saad Aldin 
Added Date : Monday, May 31, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
الهام محمد الشريحيAl-Shurihi, Elham MohmmedResearcherMaster 

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